Tomás is a meek man on the verge of a nervous breakdown. Despite his situation he decides to fake a work trip to go to Vallarta to confront Jero, a taxi driver who is sleeping with his wife.

When a not-so-successful stand up comedian has to move in with his mother who has been diagnosed with dementia, he has to learn how to cope with that new reality and the problems and responsibilities it carries as he finds out he can use that to grow his career and his love for his mom.

70-year-old Malena gets a second chance at life when she magically turns into her 22-year-old self.

De Viaje Con Los Derbez follows the fun and endearing Derbez family as they discover new cultures in foreign lands.